Madonna is not one to shy away from anything Madonna related. That's why, when Drake started paying her some attention via Instagram, her little Madonna ears perked up and she took notice.
Then things got super weird (as if they weren't already).
Not to get all Freudian on everyone, but Drake is a fan of moms and older women in general.
So, when Drake dropped If You're Reading This It's Too Late (which included a track called "Madonna"), the popstar couldn't just not respond.
It's also worth remembering that Madonna has an album that she is trying to promote and news that Drake has topped Billboard charts would likely seem lucrative to the singer.